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2020, Vol.49, No.5

530-533

Specific Binding of an Anionic Phthalocyanine Derivative to G-Quadruplex DNAs

Mami Uchiyama ,1Atsuya Momotake ,1Nagao Kobayashi ,2 and Yasuhiko Yamamoto *1,3
1Department of Chemistry, University of Tsukuba, Tsukuba, Ibaraki 305-8571, Japan
2Faculty of Textile Science and Technology, Shinshu University, Ueda, Nagano 386-8567, Japan
3Tsukuba Research Center for Energy Materials Science (TREMS), University of Tsukuba, Tsukuba, Ibaraki 305-8571, Japan
https://doi.org/10.1246/cl.200110

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Abstract

An anionic phthalocyanine derivative, 2,9(10),16(17),23(24)-tetrakis(carboxyl)phthalocyanine copper(II) complex (CuTCPc), exhibited G-quadruplex DNA specific binding. CuTCPc binds selectively to the 3′-terminal G-quartet, i.e., G6 G-quartet, of the all parallel-stranded tetrameric G-quadruplex of d(TTAGGG), and the specific binding of CuTCPc to the G6 G-quartet is inhibited by the addition of an extra T at the 3′-terminal of the constituent sequence, i.e., d(TTAGGGT).

figure

An anionic phthalocyanine derivative, 2,9(10),16(17),23(24)-tetrakis(carboxyl)phthalocyanine copper(II) complex (CuTCPc), exhibited G-quadruplex DNA specific binding. CuTCPc binds selectively to the 3′-terminal G-quartet, i.e., G6 G-quartet, of the all parallel-stranded tetrameric G-quadruplex of d(TTAGGG), and the specific binding of CuTCPc to the G6 G-quartet is inhibited by the addition of an extra T at the 3′-terminal of the constituent sequence, i.e., d(TTAGGGT).

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