2005, Vol.34, No.5

This account summarizes recent developments in the use of cheap, benign, and non-toxic iron salts as precatalysts for various cross coupling reactions. Although not yet nearly as mature as their palladium- or nickel-catalyzed counterparts, these transformations provide efficient and scalable solutions for many types of C–C-bond formations. Selected applications to the total synthesis of bioactive natural products illustrate the present state of the art.