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2011, Vol.40, No.11

1264-1266

Fe3O4/o-Carboxymethyl Chitosan/Curcumin-based Nanodrug System for Chemotherapy and Fluorescence Imaging in HT29 Cancer Cell Line

Thu Ha Phuong 1 , Huong Le Thi Thu 2 , Nhung Hoang Thi My 3 , Tham Nguyen Thi 3 , Tu Nguyen Dac 3 , Thi Ha Thi Minh 4 , Hanh Pham Thi Bich 5 , Nguyet Tran Thi Minh 1 , Quy Nguyen Thi 3 , Nam Pham Hong 1 , Lam Tran Dai 1 , Phuc Nguyen Xuan 1 , Quang Duong Tuan 6 ... Show all
1 Institute of Materials Science
2 Hanoi University of Agriculture
3 Hanoi University of Science, Vietnam National University
4 Hue University of Medicine and Pharmacy
5 Institute of Chemistry, Vietnam Academy of Science and Technology
6 Department of Chemistry, Hue University
https://doi.org/10.1246/cl.2011.1264

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Abstract
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A multifunctional nanodrug system containing Fe3O4, o-carboxymethyl chitosan (OCMCs), and curcumin (Cur) has been prepared and characterized by infrared and fluorescence spectroscopy, X-ray diffraction (XRD), and field-emission scanning electron microscopy (FE-SEM). The fluorescent staining experiments showed that this system not only had no effect on the cell internalization ability of curcumin but also successfully led curcumin into the HT29 cells as expected. From real-time cell analysis (RTCA), the effect of Fe3O4/OCMCs/Cur on this cancer cell line was found to be much stronger than that of pure curcumin. This system contained magnetic particles and, therefore, could be also considered for hyperthermia therapy in cancer treatment.

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