3-Azidoarynes: Generation and Regioselective Reactions
2Institute for Materials Chemistry and Engineering, Kyushu University, 6-1 Kasuga-koen, Kasuga, Fukuoka 816-8580, Japan
The generation of 3-azidoarynes from o-iodoaryl triflate-type precursors was achieved using a silylmethyl Grignard reagent as the activator. The azido group served to control the regioselectivity of the reaction of 3-azidoarynes with arynophiles. The remaining azido group in the adduct also served as a transformable functional group, enabling further derivatization to various nitrogen-containing compounds.